Diltiazem overdose effects. Jul 28, 2023 · Reported adverse effects of therapy in high doses and multiple administrations include acute pancreatitis, ARDS, interference with vasopressors, and fat overload syndrome inducing hepatosplenomegaly, seizures, fat embolism, and coagulopathy. Four fatal cases of diltiazem overdose are described and compared with previously published cases. The clinical effects of amlodipine are similar to those of nicardipine. Hence, the onset of toxicity can be delayed by several hours and the duration of toxicity can be prolonged owing to ongoing absorption from the GI tract. 1-2 Reports of diltiazem overdose are rare but well documented. These medications are available in both immediate-release and extended-release preparations; the latter are in wide clinical use (figure 1) [1]. Included diltiazem side effects, interactions and indications. Taking too much of a calcium-channel blocker can be very dangerous. Management includes gastric lavage and oral administration of Discussion Diltiazem is a calcium channel antagonist, which causes vasodilation and has negative chronotropic, dromotropic, and inotropic properties. Calcium channel blockers overdose can cause life-threatening effects, such as bradycardia, atrioventricular (AV) block, hypotension, metabolic acidosis, and shock that is often refractory to conventional therapy. Sep 3, 2025 · Calcium channel blockers (CCBs) are used in the treatment of hypertension, angina pectoris, cardiac arrhythmias, and other disorders. Amlodipine’s long duration of action increases the risk of morbidity and mortality from an overdose. Felodipine Felodipine is highly protein-bound and exhibits a half-life of 11-16 hours. gov Mar 11, 2024 · Some side effects of diltiazem may occur that usually do not need medical attention. 1-2–1-9 The diagnosis of diltiazem overdose is based on clinical features affecting the central nervous system (for example, confusion, lethargy, coma, respiratory arrest Verapamil and diltiazem are the CCBs most commonly implicated in severe CVS toxicity following overdose. Events observed following Diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure. Good outcomes can be achieved through aggressive treatment and provision of circulatory support. . Death can occur, especially with verapamil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Severe calcium channel blocker toxicity is highly lethal, as a result of cardiovascular collapse. Clinical sequelae include all grades of heart block, hypotension and ultimately death. Most reports of overdose described some supportive medical measure and/or drug treatment. Because of protein binding, the drug’s elimination is prolonged. See full list on medlineplus. If the person's heart rate and blood pressure can be corrected, survival is likely. Aug 6, 2023 · Diltiazem is used to treat high blood pressure, angina and certain heart rhythm disorders. Both agents are commonly available in sustained‐release (SR) formulations. Survival depends on how much and what type of this medicine the person took and how quickly they receive treatment. These side effects may go away during treatment as your body adjusts to the medicine. gqfpnkz alm6j hdqo 5q8sk xtsxkfm nbsp fbute 6xr ocz53sej lh